• Surviving Sepsis

    Surviving Sepsis

    by improving vascular integrity
    Septic shock - the killer #1 on intensive care units - results from
    loss of vascular integrity
  • Adrenomedullin

    Adrenomedullin

    Key regulator of vascular integrity
    The vasoactive hormone is highly elevated in patients with septic shock
    indicating the body's need to improve endothelial barrier function
  • Adrecizumab

    Adrecizumab

    Improving Vascular Integrity
    The humanized monoclonal anti-ADM antibody modulates Adrenomedullin
    activity and improves vascular integrity & sepsis survival

Improving vascular integrity in Sepsis ... and beyond

8 million people die from sepsis each year worldwide, despite antibiotics and intensive care. Adrenomed aims to prevent the fatal septic shock by modulating the activity of the vasoactive hormone Adrenomedullin (ADM), a key regulator of vascular integrity.

Our first-in-class clinical stage drug candidate Adrecizumab is a humanized monoclonal ADM-specific antibody that improves endothelial barrier function and prevents vascular leakage. After demonstrating excellent tolerability, safety & efficacy in preclinical animal models and healthy subjects, Adrecizumab will now be tested first in a stratified clinical phase II study in early septic shock.

Recent Publications

Effects of the humanized anti-Adrenomedullin antibody Adrecizumab on vascular barrier function and survival during systemic inflammation and sepsis 

C.B.C.A.G. Geven,  E. Peters,  J. Struck,  A. Bergmann,  O. McCook, P. Radermacher, M. Kox, P. PickkersIntensive  Care  Medicine  Experimental 2017, 5(Suppl 2): 0429 | PDF  

Safety, tolerability and pharmacokinetics/-dynamics of the anti-adrenomedullin antibody Adrecizumab: a first in man study

C.B.C.A.G. Geven, M. Kox, P. Scigalla, A. Bergmann, E. Peters, P. Pickkers: Intensive Care Medicine Experimental 2017, 5(Suppl 2):0427 | PDF  

Circulating Biologically Active Adrenomedullin (bio-ADM) Predicts Hemodynamic Support Requirement and Mortality During Sepsis

Pietro Caironi, MD; Roberto Latini, MD; Joachim Struck, PhD; Oliver Hartmann, PhD; Andreas Bergmann, PhD; Giuseppe Maggio, MD; Marco Cavana, MD; Gianni Tognoni, MD; Antonio Pesenti, MD; Luciano Gattinoni, MD; and Serge Masson, PhD; on behalf of the ALBIOS Study Investigators 2017 PDF | CHEST

Sandwich Immunoassay for Bioactive Plasma Adrenomedullin

Julia Weber,Janine Sachse, Sarah Bergmann, Andrea Sparwaßer, Joachim Struck and Andreas Bergmann; September 2017 | 02:02 | 000 PDF | JALM 

Plasma adrenomedullin in critically ill patients with sepsis after major surgery: A pilot study

Tim-Philipp Simon, MD a, Lukas Martin, MD a, Sabine Doemming, MD a, Andreas Humbs a, Christian Bruells, MD a, Ruedger Kopp, MD a, Oliver Hartmann, ScDb, Joachim Struck, ScD b, Andreas Bergmann, ScD b, Gernot Marx,MDa, Tobias Schuerholz, MD; Journal of Critical Care 38 (2016) 68–72 PDF | JCC

Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure

Alexandre Mebazaa, Pierre François Laterre, James A. Russell, Andreas Bergmann, Luciano Gattinoni, Etienne Gayat, Michael O. Harhay, Oliver Hartmann, Frauke Hein, Anne Louise Kjolbye, Matthieu Legrand, Roger J. Lewis, John C. Marshall, Gernot Marx, Peter Radermacher, Mathias Schroedter, Paul Scigalla, Wendy Gattis Stough, Joachim Struck, Greet Van den Berghe, Mehmet Birhan Yilmaz and Derek C. Angus; Journal of Intensive Care 2016, 4:24 PDF | PubMed

Hemodynamics effects of Adrecizumab in sepsis rat

Blet A, Sadoune M , Polidano E , Merval R, Bernard C , Samuel JL and Mebazaa A, Intensive Care Medicine Experimental, 2015, 3(Suppl 1):A618 | PDF

Endothelial Barrier Injury is directly related to Kidney Dysfunction in resuscitated murine shock model

Zink F, Stenzel T, Wachter U, Vogt J, McCook O, Radermacher P.,  Shock 2015, 44 Suppl 2:15-6. | Website | F1000Prime

Plasma adrenomedullin is associated with short-term mortality and vasopressor requirement in patients admitted with sepsis

Rossella Marino, Joachim Struck, Alan S Maisel, Laura Magrini, Andreas Bergmann and Salvatore Di Somma, Critical Care 2014, 18(1):R34 | PDF | PubMed

Adrenomedullin: it's double-edged sword during sepsis slices yet again

Kox M, Pickkers P, (Editorial) Intensive Care Medicine Experimental, 2014, 2:1 | PDF

Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock

Katja Wagner, Ulrich Wachter, Josef A Vogt, Angelika Scheuerle, Oscar McCook, Sandra Weber, Michael Gröger, Bettina Stahl, Michael Georgieff, Peter Möller, Andreas Bergmann, Frauke Hein, Enrico Calzia, Peter Radermacher, Florian Wagner, Intensive Care Medicine Experimental 2013, 1:2 | PDF | PubMed

Epitope specificity of anti-Adrenomedullin antibodies determines efficacy of mortality reduction in a cecal ligation and puncture mouse model

Joachim Struck, Frauke Hein, Siegmund Karasch, Andreas Bergmann, Intensive Care Medicine Experimental 2013, 1:3 PDF | PubMed