• Imagine

    Imagine

    we could save lives
    Impairment of vascular integrity is a hallmark of numerous medical conditions
    including systemic inflammation and cardiovascular diseases

Company profile

Adrenomed AG is a privately-financed biopharmaceutical company with a clear mission: to improve vascular integrity in order to improve survival. Adrenomed was established in 2009 by Dr. Bernd Wegener and Dr. Andreas Bergmann, co-founders & former executive managers of BRAHMS AG. They changed the standard of care in sepsis by developing Procalcitonin (B.R.A.H.M.S. PCTTM), the diagnostic gold standard sepsis biomarker.

We are focusing on the discovery and development of monoclonal antibody therapies that target the vasoactive Adrenomedullin system as a new strategy for causative and safe treatment of acute circulatory failure, e.g. septic shock. Our lead product is the first-in-class drug candidate Adrecizumab, a humanized monoclonal Adrenomedullin-specific antibody . Adrenomedullin is a vasoactive peptide hormone released by vascular endothelial cells. During sepsis, the impairment of the endothelial barrier leads to collapse of blood pressure (septic shock) which frequently results in multiple organ failure and death. Adrenomedullin is a key regulator of vascular integrity and plays a pivotal role in the development of septic shock. Adrecizumab has an innovative mode of action that spatially controls Adrenomedullin activity, thereby reducing vascular leakage, stabilizing the circulation and lowering mortality.

 

Board of Directors

Dr. Bernd Wegener | Chief Executive Officer (CEO)

Dr. Andreas Bergmann  | Chief Scientific Officer (CSO)

 

Senior Management

The virtual nature of the company leads to a very lean personnel structure that mainly focusses on project management. The key competences for planning and evaluation of the preclinical and clinical study program as well as CMC development are in-house capabilities; all operational resources are third party based capacities. The experienced sepsis research for decades resulted in an extensive network with key opinion leaders worldwide in cardiovascular disease and sepsis that support Adrenomed’s clinical research.

Prof. Paul Scigalla | Chief Medical Officer (CMO)

Dr. Frauke Hein | Chief Business Officer (CBO)

Dr. Joachim Struck | Head of Research & Development

 

Regulatory Consultants

Granzer Regulatory Consulting & Services

 

Supervisory Board

Renke Lührs (Chairman) | Corporate Lawyer & Partner of Buse Heberer Fromm Rechtsanwälte Steuerberater Partnerschaftsgesellschaft in Berlin

Dr. Gerald Moeller | Co-founder of Adrenomed with over 35 years of Management Experience in the Diagnostic and Pharmaceutical Industry

Dr. Metod Miklus | CEO of ExpoCapital GmbH and Co-founder of BRAHMS

 

Publications

  • Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure

Alexandre Mebazaa, Pierre François Laterre, James A. Russell, Andreas Bergmann, Luciano Gattinoni, Etienne Gayat, Michael O. Harhay, Oliver Hartmann, Frauke Hein, Anne Louise Kjolbye, Matthieu Legrand, Roger J. Lewis, John C. Marshall, Gernot Marx, Peter Radermacher, Mathias Schroedter, Paul Scigalla, Wendy Gattis Stough, Joachim Struck, Greet Van den Berghe, Mehmet Birhan Yilmaz and Derek C. Angus, IJournal of Intensive Care 2016, 4:24 PDF | PubMed

  • Epitope specificity of anti-Adrenomedullin antibodies determines efficacy of mortality reduction in a cecal ligation and puncture mouse model

Joachim Struck, Frauke Hein, Siegmund Karasch, Andreas Bergmann, Intensive Care Medicine Experimental 2013, 1:3 PDF | PubMed

  • Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock

Katja Wagner, Ulrich Wachter, Josef A Vogt, Angelika Scheuerle, Oscar McCook, Sandra Weber, Michael Gröger, Bettina Stahl, Michael Georgieff, Peter Möller, Andreas Bergmann, Frauke Hein, Enrico Calzia, Peter Radermacher, Florian Wagner, Intensive Care Medicine Experimental 2013, 1:2 | PDF | PubMed

  • Plasma adrenomedullin is associated with short-term mortality and vasopressor requirement in patients admitted with sepsis

Rossella Marino, Joachim Struck, Alan S Maisel, Laura Magrini, Andreas Bergmann and Salvatore Di Somma, Critical Care 2014, 18(1):R34 | PDF | PubMed

  • Hemodynamics effects of Adrecizumab in sepsis rat

Blet A, Sadoune M , Polidano E , Merval R, Bernard C , Samuel JL and Mebazaa A, Intensive Care Medicine Experimental, 2015, 3(Suppl 1):A618 | PDF

  • Endothelial Barrier Injury is directly related to Kidney Dysfunction in resuscitated murine shock model

Zink F, Stenzel T, Wachter U, Vogt J, McCook O, Radermacher P.,  Shock 2015, 44 Suppl 2:15-6. | Website | F1000Prime

  • Adrenomedullin: it's double-edged sword during sepsis slices yet again

Kox M, Pickkers P, (Editorial) Intensive Care Medicine Experimental, 2014, 2:1 | PDF

  • Sepsis bekämpfen - Leben retten

Andreas Bergmann in |transkript 3/2016 | Website (german)

Press Releases

August 11, 2017: Adrenomed AG receives approval to conduct proof of concept study with Adrecizumab to treat patients with Early Septic Shock | download

March 08, 2017: Phase I successfully completed | Adrecizumab is safe, well tolerated and shows additional therapeutic potential in acute heart failure | download

References

  1. Angus et al. (2010) The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med 2010; 36(2): 222-231.
  2. U.S. National Hospital Discharge Survey (2008) www.cdc.gov
  3. Kitamura et al. (1993) Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun, 192: 553-60.
  4. Temmesfeld-Wollbrück et al. (2007) Adrenomedullin and endothelial barrier function. Thromb Haemost. 98(5): 944-51.
  5. Temmesfeld-Wollbrück et al. (2007) Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock. Intensive Care Med. 33(4): 703-10.
  6. Koyama et al. (2013) Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis. Circulation. 127(7): 842-53.
  7. Wagner et al. (2012) Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock, Intensive Care Medicine Experimental, 1:2.
  8. Karpinich et al. (2011) Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models. Curr Hypertens Rev, 7(4):228-239.