Sepsis & Septic Shock
Impaired vascular integrity in sepsis results in organ failure & shock
Sepsis is a life-threatening medical condition caused by an overwhelming reaction of the immune system to a severe infection. The systemic inflammation results in an acute impairment of the vascular endothelial barrier, leading to vascular leakage and acute circulatory failure (septic shock). Diminished perfusion of internal organs with oxygens finally leads to multiple organ failure and death.
Early treatment with antibiotics and hemodynamic support represent the current standard of care in sepsis management. However, despite considerable improvement in the development of novel antibacterial agents and immunomodulatory therapies, sepsis incidence rate has doubled in the past 10 years and the mortality rate still remains high at approx. 30%. Once the patient developes a septic shock the mortality rate coverges to 50-80% [1,2].